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Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
Alexander Tuzikov , Ph.D.





Date and place of birth: March 21, 1958, Kimry, Tver region, Russia

Martial status: married

Affiliation and official address: Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia



Moscow State University, Department of Chemistry, 1975-1980. M.Sc. Thesis " Anionic s-complexes of trinitrobenzene, containing Me3ECH2 groups (E = Si, Ge, Sn)", Supervisor Dr. G. A. Artamkina; Laboratory of Theoretical Problems.

1988 - Ph.D. Thesis "Intramolecular hydroacylation of unsaturated aldehydes catalyzed by cobalt complexes", Supervisors: Dr.Sci. M. G. Vinogradov, Prof. G. I. Nikishin; Laboratory of Homolytic Reactions, Zelinsky Institute of Organic Chemistry.



1980 - Research scientist of Laboratory of Homolytic Reactions, Zelinsky Institute of Organic Chemistry, Moscow.

1990-present time - Senior scientist of Laboratory Carbohydrate Chemistry, Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry, Moscow.



chemistry; supramolecular chemistry; biochemistry; sialic acids; biochemistry of glycoconjugates; carbohydrate-protein interactions; chemo-medical approaches in influenza, bacterial infections.



experience in organic synthesis; oligosaccharide synthesis; peptide synthesis; multivalent glycoconjugates synthesis; experience of handling with NMR, IR, Raman, mass-spectra, atomic force microscopy and electron microscopy data.



supramolecular chemistry; oligosaccharide synthesis; multivalent glycoconjugates synthesis; carbohydrate-protein interaction; immune response to carbohydrates; biomedical applications of supramolecular chemistry and nanotechnology. 

Position: senior scientist
Fax: +7 495 330-55-92
E.mail:  Send mail

Publications: (total 75, shown from 1 to 30) [print version]

1. G.V.Pazynina, I.S.Popova, I.M.Belyanchikov, A.B.Tuzikov, N.V.Bovin
Synthesis of trisaccharide 6'SiaLeC and its 6-O-Su derivative.
Mendeleev Communs., 22(4), pp.194-195, (2012) [abstract]

2. E.Yu.Korchagina, A.B.Tuzikov, A.A.Formanovsky, I.S.Popova, S.Henry, N.V.Bovin
Toward creating cell membrane glyco-landscapes with glycan lipid constructs.
Carbohydrate Research, 356, pp.238-246, (2012) [abstract] [full PDF] [PMID: 22551471]

3. S.V.Tsygankova, A.A.Chinarev, A.B.Tuzikov, I.S.Zaitsev, N.Severin, A.A.Kalachev, J.P.Rabe, N.V.Bovin
Assembly of oligoglicine layers on mica surface.
Biomater. Nanobiotechnol., 2, pp.90-96, (2011) [abstract] [full PDF]

4. A.A.Chinarev, A.B.Tuzikov, A.I.Zinin, N.V.Bovin
Substituted Benzyl Glycosides of N-Acetylneuraminic Acid
In Carbohydrate Chemistry Proven Methods Vol. 1., Kovac, P., (ed.) CRC PressTaylor Francis, Boca Raton, FL, pp.251-258, (2011) [abstract]

5. V.V.Prokhorov, D.V.Klinov, A.A.Chinarev, A.B.Tuzikov, I.V.Gorokhova, N.V.Bovin
High-resolution atomic force microscopy study of hexaglycylamide epitaxial structures on graphite.
Langmuir, 27, pp.5879-5880, (2011) [abstract] [full PDF] [PMID: 21351798]

6. E.M.Hadac, M.J.Federspiel, E.Cherny, A.B.Tuzikov, E.Yu.Korchagina, N.V.Bovin, S.Russell, S.Henry
Fluorescein and radiolabeled Function-Spacer-Lipid constructs allow for simple in vitro and in vivo bioimaging of enveloped virions
J. Virol. Methods, 176(1-2), pp.78-84, (2011) [abstract] [PMID: 21703308]

7. P.Obukhova, V.E.Piskarev, V.V.Severov, G.V.Pazynina, A.B.Tuzikov, M.Navakouski, N.V.Shilova, N.V.Bovin
Profiling of serum antibodies with printed glycan array: room for data misinterpretation.
Glycoconjugate Journal, 28(8-9), pp.501-505, (2011) [abstract] [PMID: 22057658]

8. D.Heathcote, T.Carroll, J.J.Wang, R.Flower, I.Rodionov, A.B.Tuzikov, N.V.Bovin, S.Henry
Novel antibody screening cells, MUT+Mur kodecytes, created by attaching peptides onto red blood cells.
Transfusion, 50(3), pp.635-41, (2010) [abstract] [PMID: 19912581]

9. D.Heathcote, T.Carroll, J.J.Wang, R.Flower, I.Rodionov, A.B.Tuzikov, N.V.Bovin
Novel antibody screening cells, MUT+Mur kodecytes, created by attaching peptides onto erythrocytes.
Transfusion, 50(3), pp.635-641, (2010) [abstract] [PMID: 19912581]

10. P.A.Chugunov, A.A.Chinarev, A.B.Tuzikov, A.A.Formanovsky, A.S.Gambaryan, N.V.Bovin
Monosialoside with multimer-like anti-influenza potency.
Mendeleev Communs., 19(2), pp.62-63, (2009) [abstract] [full PDF]

11. G.V.Pazynina, M.A.Sablina, M.Mayzel, V.V.Nasonov, A.B.Tuzikov, N.V.Bovin
Chemical synthesis of 6(GlcNAc)- and 6(Gal)-O-sulfated SiaLeX tetrasaccharides in spacer-armed form.
Glycobiology, 19(10), pp.1078-1081, (2009) [abstract] [full PDF] [PMID: 19584101]

12. M.E.Huflejt, M.Vuskovic, D.Vasiliu, P.Obukhova, N.V.Shilova, A.B.Tuzikov, O.E.Galanina, N.V.Bovin, etc.
Anti-carbohydrate antibodies of normal sera: findings, surprises and challenges.
Molecular Immunolology, 46(15), pp.3037-3049, (2009) [abstract] [PMID: 19608278]

13. A.S.Gambaryan, A.B.Tuzikov, G.V.Pazynina, J.A.Desheva, N.V.Bovin, M.N.Matrosovich, A.Klimov
6-sulfo sialyl Lewis X is the common receptor determinant recognized by H5, H6, H7 and H9 influenza viruses of terrestrial poultry.
Virol J., 5(1), p.85, (2008) [abstract] [PMID: 18652681]

14. N.V.Bovin, A.B.Tuzikov, A.A.Chinarev
Oligoglycines: Materials with unlimited potential for nanotechnologies.
Nanotechnologies in Russia, 3(5-6), pp.48-61, (2008) [abstract] [full PDF]

15. N.E.Byramova, A.B.Tuzikov, T.V.Tyrtysh, N.V.Bovin
1,6-Anhydro-N-Acetylβ-D-Glucosamine in Oligosaccharide Synthesis: II.1 The Synthesis of the Spacered Ley Tetrasaccharide. [Article in Russian]
Russ. J. Bioorgan. Chem., 33(1), pp.108-118, (2007) [abstract] [full PDF] [PMID: 17375666]

16. A.S.Gambaryan, A.B.Tuzikov, G.V.Pazynina, N.V.Bovin, A.Balish, A.Klimov
Evolution of the receptor binding phenotype of influenza A (H5) viruses
Virology, 344(2), pp.432-438, (2006) [abstract] [full PDF] [PMID: 16226289]

17. I.V.Gorokhova, A.A.Chinarev, A.B.Tuzikov, S.V.Tsygankova, N.V.Bovin
Spontaneous and promoted association of linear oligoglycines. [Article in Russian]
Russ. J. Bioorgan. Chem., 32(5), pp.467-476, (2006) [abstract] [full PDF] [PMID: 17042264]

18. A.S.Gambaryan, V.P.Marinina, T.A.Solodar', N.V.Bovin, A.B.Tuzikov, G.V.Pazynina, S.S.Yamnikova, D.K.Lvov, etc.
Different receptor specificity of influence viruses from ducks and chickens and its reflection in the composition of sialosides on host cells and mucins. [Article in Russian]
Vopr. Virusol. (Rus.), 51(4), pp.24-32, (2006) [abstract] [PMID: 16929595]

19. N.V.Shilova, O.E.Galanina, T.V.Pochechueva, A.A.Chinarev, V.A.Kadykov, A.B.Tuzikov, N.V.Bovin
High molecular weight neoglycoconjugates for solid phase assays.
Glycoconjugate Journal, 22(1-2), pp.43-51, (2005) [abstract] [full PDF] [PMID: 15864434]

20. A.S.Gambaryan, S.S.Yamnikova, D.K.Lvov, A.B.Tuzikov, A.A.Chinarev, G.V.Pazynina, R.G.Webster, M.N.Matrosovich, etc.
Receptor specificity of influenza viruses from birds and mammals: New data on involvement of the inner fragments of the carbohydrate chain
Virology, 334(2), pp.276-283, (2005) [abstract] [full PDF] [PMID: 15780877]

21. A.S.Gambaryan, A.I.Karasin, A.B.Tuzikov, A.A.Chinarev, G.V.Pazynina, N.V.Bovin, M.N.Matrosovich, C.W.Olsen, etc.
Receptor-binding properties of swine influenza viruses isolated and propagated in MDCK cells
Virus Res., 114(1-2), pp.15-22, (2005) [abstract] [full PDF] [PMID: 15996787]

22. A.S.Gambaryan, E.Y.Boravleva, M.N.Matrosovich, H.-d.Klenk, E.V.Moiseeva, A.B.Tuzikov, A.A.Chinarev, G.V.Pazynina, etc.
Polymer-bound 6'sialyl-N-acetyllactosamine protects mice infected by influenza virus
Antiviral Research, 68(3), pp.116-123, (2005) [abstract] [full PDF] [PMID: 16214231]

23. A.S.Gambaryan, A.B.Tuzikov, G.V.Pazynina, R.G.Webster, M.N.Matrosovich, N.V.Bovin
H5N1 chicken influenza viruses display a high binding affinity for Neu5Acα2-3Galβ1-4(6-HSO3)GlcNAc-containing receptors.
Virology, 326(2), pp.310-316, (2004) [abstract] [full PDF] [PMID: 15302215]

24. N.V.Bovin, A.B.Tuzikov, A.A.Chinarev, A.S.Gambaryan
New approaches to antiviral therapy.
Molecular Medicine (Rus.), 3, pp.56-61, (2004)

25. E.I.Vodovozova, G.V.Pazynina, A.B.Tuzikov, I.V.Grechishnikova, J.G.Molotkovsky
Synthesis of photoreactive neoglycolipid probes--instruments for studying membrane lectins. [Article in Russian]
Russ. J. Bioorgan. Chem., 30(2), pp.154-160, (2004) [full PDF] [PMID: 15143673]

26. N.A.Ilyushina, I.A.Rudneva, A.S.Gambaryan, A.B.Tuzikov, N.V.Bovin
Receptor specificity of H5 influenza virus escape mutants.
Virus Res., 100(2), pp.237-241, (2004) [abstract] [PMID: 15019242]

27. V.P.Marinina, A.S.Gambaryan, A.B.Tuzikov, G.V.Pazynina, N.V.Bovin, I.T.Fedyakina, S.S.Iamnikova, D.K.Lvov, etc.
Evolution of the receptor specificity of influenza viruses hemagglutinin in its transfer from duck to pig and man. [Article in Russian]
Vopr. Virusol. (Rus.), 49(3), pp.25-30, (2004) [abstract] [PMID: 15188651]

28. N.V.Bovin, A.B.Tuzikov, A.A.Chinarev, A.S.Gambaryan
Multimeric glycotherapeutics: new paradigm.
Glycoconjugate Journal, 21(8-9), pp.471-478, (2004) [abstract] [full PDF] [PMID: 15750788]

29. G.V.Pazynina, M.A.Sablina, A.B.Tuzikov, A.A.Chinarev, N.V.Bovin
Synthesis of complex α2-3 sialooligosaccharides, including sulfated and fucosylated ones, using Neu5Acα2-3Gal as a building block.
Mendeleev Communs., 13, pp.245-248, (2003) [abstract] [full PDF]

30. S.S.Yamnikova, A.S.Gambaryan, A.B.Tuzikov, N.V.Bovin, M.N.Matrosovich, I.T.Fedyakina, A.A.Grinev, V.M.Blinov, etc.
Differences Between HA Receptor-Binding Sites of Avian Influenza Viruses Isolated from Laridae and Anatidae.
Avian Diseases, 47(3), pp.1164-1168, (2003) [abstract] [full PDF] [PMID: 14575135]

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