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Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
Galina Pazynina , Ph.D.

PERSONAL DATA:

Dare and place of birth: September 18, 1958, Krasnogorsk, Moscow region, Russia

Martial status: divorcee

Nationality: Russian

Affiliation and official address: Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

 

EDUCATION:

Moscow State University, Department of Chemistry, 1975-1981. M.Sc. Thesis "Condensation of diazo-compounds with olefins in the presence of homogeneous catalysts", Supervisor Dr. I. G. Bolesov; Laboratory of Organic Synthesis.

1988 - Ph.D. Thesis "Phtalocyanines of transition metals in the cyclopropanation reactions of unsaturated compounds with ethyldiazoacetate", Supervisors: Dr.Sci. I. G. Bolesov, Laboratory of Organic Synthesis, Department of Chemistry, Moscow State University; Prof. E. A. Lukyanets, Scientific and Research Institute of Organic Semiproducts and Dyes (NIOPIK), Moscow.

 

SCIENTIFIC CARRIER:

1981-1984 postgraduate, Scientific and Research Institute of Organic Semiproducts and Dyes (NIOPIK), Moscow.

1984-1992 - Research scientist, Scientific and Research Institute of Organic Semiproducts and Dyes (NIOPIK), Moscow.

1992-present time - Research scientist of Laboratory Carbohydrate Chemistry, Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry, Moscow.

 

JOB OBJECTIVE:

chemistry; biochemistry; carbohydrate synthesis; sialic acids; biochemistry of glycoconjugates; carbohydrate-protein interactions.

 

QUALIFICATIONS:

experience in organic synthesis; oligosaccharide synthesis; multivalent glycoconjugates synthesis; experience of handling with NMR, IR and mass-spectra data.

 

CURRENT RESEARCH INTERESTS:

oligosaccharide synthesis; multivalent glycoconjugates synthesis; carbohydrate-protein interaction; influenza virus; influenza therapy; oncodiagnostics and oncotargeting.



Position: staff researcher
Phone: +7 495 330-61-29; Fax: +7 495 330-55-92
E.mail:  Send mail


Publications: (total 44, shown from 1 to 30) [print version]

1. G.V.Pazynina, T.V.Tyrtysh, V.V.Nasonov, I.M.Belyanchikov, A.Paramonov, N.Malysheva, L.O.Kononov, N.V.Bovin, etc.
Divergent strategy for the synthesis of α2-3-linked sialo-oligosaccharide libraries using a Neu5TFA-(α2-3)-Gal building block.
Synlett, 24, pp.226-230, (2013) [abstract]

2. G.V.Pazynina, I.S.Popova, I.M.Belyanchikov, A.B.Tuzikov, N.V.Bovin
Synthesis of trisaccharide 6'SiaLeC and its 6-O-Su derivative.
Mendeleev Communs., 22(4), pp.194-195, (2012) [abstract]

3. O.A.Vokhmyanina, E.M.Rapoport, S.André, V.V.Severov, I.M.Ryzhov, G.V.Pazynina, E.Yu.Korchagina, N.V.Bovin, etc.
Comparative study of the glycan specificities of cell-bound human tandem-repeat-type galectin-4, -8 and -9.
Glycobiology, 22(1), pp.207-217, (2012) [abstract] [full PDF] [PMID: 22547138]

4. E.I.Vodovozova, G.V.Pazynina, N.V.Bovin
Synthesis of diglyceride conjugate of selectin ligand SiaLeX as a vector for targeting of drug-loaded liposomes.
Mendeleev Communs., 21(2), pp.69-71, (2011) [abstract]

5. P.Obukhova, V.E.Piskarev, V.V.Severov, G.V.Pazynina, A.B.Tuzikov, M.Navakouski, N.V.Shilova, N.V.Bovin
Profiling of serum antibodies with printed glycan array: room for data misinterpretation.
Glycoconjugate Journal, 28(8-9), pp.501-505, (2011) [abstract] [PMID: 22057658]

6. O.A.Vokhmyanina, E.M.Rapoport, I.M.Ryzhov, E.Yu.Korchagina, G.V.Pazynina, V.V.Severov, H.-J.Gabius, N.V.Bovin, etc.
Carbohydrate specificity of chicken and human tandem-repeat-type galectins-8 in composition of cells.
Biochemistry (Moscow), 76(10), pp.1185-1192, (2011) [abstract]

7. G.V.Pazynina, M.A.Sablina, V.V.Nasonov, Y.E.Pustovalova, I.M.Belyanchikov, N.V.Bovin
Synthesis of GalNAcβ1-4GlcNAcβ (LacdiNAc) O-sulfates.
Mendeleev Communs., 20(6), pp.316-317, (2010) [abstract]

8. O.V.Kurmyshkina, E.M.Rapoport, E.V.Moiseeva, E.Yu.Korchagina, T.V.Ovchinnikova, G.V.Pazynina, I.M.Belyanchikov, N.V.Bovin
Glycoprobes as a tool for the study of lectins expressed on tumor cells.
Acta Histochem., 112(2), pp.118-126, (2010) [abstract] [PMID: 19285339]

9. O.V.Kurmyshkina, E.M.Rapoport, E.V.Moiseeva, E.Yu.Korchagina, T.V.Ovchinnikova, G.V.Pazynina, I.M.Belyanchikov, N.V.Bovin
Glycoprobes as a tool for the study of lectins expressed on tumor cells.
Acta Histochem., 112, pp.118-126, (2010) [abstract] [PMID: 19285339]

10. E.M.Rapoport, T.V.Pochechueva, O.V.Kurmyshkina, G.V.Pazynina, V.V.Severov, I.M.Belyanchikov, H.-J.Gabius, N.V.Bovin, etc.
Solid-phase assays for study of carbohydrate specificity of galectins.
Biochemistry (Moscow), 75(3), pp.310-319, (2010) [abstract] [PMID: 20370609]

11. G.V.Pazynina, M.A.Sablina, M.Mayzel, V.V.Nasonov, A.B.Tuzikov, N.V.Bovin
Chemical synthesis of 6(GlcNAc)- and 6(Gal)-O-sulfated SiaLeX tetrasaccharides in spacer-armed form.
Glycobiology, 19(10), pp.1078-1081, (2009) [abstract] [full PDF] [PMID: 19584101]

12. G.V.Pazynina, V.V.Severov, M.L.Maisel, I.M.Belyanchikov, N.V.Bovin
Synthesis of mono-, di- and tri-O-sulfated N-acetyllactosamines in a form suitable for glycochip printing.
Mendeleev Communs., 18(5), pp.238-240, (2008) [full PDF]

13. G.V.Pazynina, V.V.Severov, N.V.Bovin
The synthesis of linear trilactosamine. [Article in Russian]
Russ. J. Bioorgan. Chem., 34(5), pp.696-703, (2008) [abstract] [PMID: 19060944]

14. E.M.Rapoport, S.André, O.V.Kurmyshkina, T.V.Pochechueva, V.V.Severov, G.V.Pazynina, H.-J.Gabius, N.V.Bovin
Galectin-loaded cells as a platform for the profiling of lectin specificity by fluorescent neoglycoconjugates: a case study on galectins-1 and -3 and the impact of assay setting.
Glycobiology, 18(4), pp.315-324, (2008) [abstract] [PMID: 18256179]

15. A.S.Gambaryan, A.B.Tuzikov, G.V.Pazynina, J.A.Desheva, N.V.Bovin, M.N.Matrosovich, A.Klimov
6-sulfo sialyl Lewis X is the common receptor determinant recognized by H5, H6, H7 and H9 influenza viruses of terrestrial poultry.
Virol J., 5(1), p.85, (2008) [abstract] [PMID: 18652681]

16. V.V.Severov, I.M.Belyanchikov, G.V.Pazynina, N.V.Bovin
Synthesis of N -Acetyllactosamine-Containing Oligosaccharides, Galectin Ligands
Russ. J. Bioorgan. Chem., 33(1), pp.131-147, (2007) [abstract] [full PDF] [PMID: 17375668]

17. E.M.Rapoport, G.V.Pazynina, M.A.Sablina, P.Crocker, N.V.Bovin
Probing Sialic Acid Binding Ig-Like Lectins (Siglecs) with Sulfated Oligosaccharides
Biochemistry (Moscow), 71(5), pp.496-504, (2006) [abstract] [full PDF] [PMID: 16732727]

18. A.S.Gambaryan, A.B.Tuzikov, G.V.Pazynina, N.V.Bovin, A.Balish, A.Klimov
Evolution of the receptor binding phenotype of influenza A (H5) viruses
Virology, 344(2), pp.432-438, (2006) [abstract] [full PDF] [PMID: 16226289]

19. A.S.Gambaryan, V.P.Marinina, T.A.Solodar', N.V.Bovin, A.B.Tuzikov, G.V.Pazynina, S.S.Yamnikova, D.K.Lvov, etc.
Different receptor specificity of influence viruses from ducks and chickens and its reflection in the composition of sialosides on host cells and mucins. [Article in Russian]
Vopr. Virusol. (Rus.), 51(4), pp.24-32, (2006) [abstract] [PMID: 16929595]

20. E.I.Vodovozova, A.V.Gordienko, G.P.Gaenko, G.V.Pazynina, N.V.Bovin, J.G.Molotkovsky
Detection of the tumor cell lectins with the help of photoaffine labelling
Biol. Membr. (Rus.), 22, pp.308-321, (2005)

21. A.S.Gambaryan, S.S.Yamnikova, D.K.Lvov, A.B.Tuzikov, A.A.Chinarev, G.V.Pazynina, R.G.Webster, M.N.Matrosovich, etc.
Receptor specificity of influenza viruses from birds and mammals: New data on involvement of the inner fragments of the carbohydrate chain
Virology, 334(2), pp.276-283, (2005) [abstract] [full PDF] [PMID: 15780877]

22. E.M.Rapoport, Yu.B.Sapot'ko, G.V.Pazynina, V.Bojenko, N.V.Bovin
Sialoside-Binding Macrophage Lectins in Phagocytosis of Apoptotic Bodies
Biochemistry (Moscow), 70(3), pp.330-338, (2005) [abstract] [full PDF] [PMID: 15823088]

23. A.S.Gambaryan, A.I.Karasin, A.B.Tuzikov, A.A.Chinarev, G.V.Pazynina, N.V.Bovin, M.N.Matrosovich, C.W.Olsen, etc.
Receptor-binding properties of swine influenza viruses isolated and propagated in MDCK cells
Virus Res., 114(1-2), pp.15-22, (2005) [abstract] [full PDF] [PMID: 15996787]

24. A.S.Gambaryan, E.Y.Boravleva, M.N.Matrosovich, H.-d.Klenk, E.V.Moiseeva, A.B.Tuzikov, A.A.Chinarev, G.V.Pazynina, etc.
Polymer-bound 6'sialyl-N-acetyllactosamine protects mice infected by influenza virus
Antiviral Research, 68(3), pp.116-123, (2005) [abstract] [full PDF] [PMID: 16214231]

25. A.S.Gambaryan, A.B.Tuzikov, G.V.Pazynina, R.G.Webster, M.N.Matrosovich, N.V.Bovin
H5N1 chicken influenza viruses display a high binding affinity for Neu5Acα2-3Galβ1-4(6-HSO3)GlcNAc-containing receptors.
Virology, 326(2), pp.310-316, (2004) [abstract] [full PDF] [PMID: 15302215]

26. E.I.Vodovozova, A.I.Nazarova, A.V.Feofanov, R.V.Kholodenko, G.V.Pazynina, G.P.Gayenko, N.V.Bovin, J.G.Molotkovsky
Interaction of liposomes bearing carbohydrate determinants with melanoma cells.
Biol. Membr. (Rus.), 21, pp.53-64, (2004)

27. E.I.Vodovozova, G.V.Pazynina, A.B.Tuzikov, I.V.Grechishnikova, J.G.Molotkovsky
Synthesis of photoreactive neoglycolipid probes--instruments for studying membrane lectins. [Article in Russian]
Russ. J. Bioorgan. Chem., 30(2), pp.154-160, (2004) [full PDF] [PMID: 15143673]

28. E.P.Smorodin, O.Kurtenkov, B.L.Sergeyev, G.V.Pazynina, N.V.Bovin
Specificity of human anti-carbohydrate IgG antibodies as probed with polyacrylamide-based glycoconjugates.
Glycoconjugate Journal, 20(2), pp.83-89, (2004) [abstract] [PMID: 15001840]

29. V.P.Marinina, A.S.Gambaryan, A.B.Tuzikov, G.V.Pazynina, N.V.Bovin, I.T.Fedyakina, S.S.Iamnikova, D.K.Lvov, etc.
Evolution of the receptor specificity of influenza viruses hemagglutinin in its transfer from duck to pig and man. [Article in Russian]
Vopr. Virusol. (Rus.), 49(3), pp.25-30, (2004) [abstract] [PMID: 15188651]

30. O.E.Galanina, M.Mecklenburg, N.E.Nifant'ev, G.V.Pazynina, N.V.Bovin
GlycoChip: multiarray for the study of carbohydrate-binding proteins.
Lab Chip., 3(4), pp.260-265, (2003) [abstract] [full PDF] [PMID: 15007456]

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