Moscow State University, Department of Chemistry, 1971-1976, M.Sc.Thesis "Synthesis and cycloaddition reactions of 3,3-disubstituted cyclopropenes", Supervisor Dr. I.G.Bolesov, Laboratoty of Organic Synthesis.
Ph.D.Thesis "Synthesis of blood group related oligosaccharides H, A, and Lea, and their immobilisation on polymeric matrix", 1982, Institute of Bioorganic Chemistry, Laboratory of Carbohydrates and Glycoproteins (Prof. A.Ya.Khorlin).
Dr.Sci. Thesis "Neoglycoconjugates: synthesis and application for hemo- and oncodiagnostics", 1993, Institute of Bioorganic Chemistry.
CARRIER/EMPLOYMENT
Research scientist - 1976, Shemyakin Institute, Moscow
Dr. (candidate, equivalent to Ph.D.) - 1982, Shemyakin Institute, Moscow
Dr. Sci., in chemistry, - 1993, Shemyakin Institute, Moscow
Head of research laboratory, Institute of Biotechnology, Moscow - 1985
Head of research laboratory, Shemyakin Institute, Moscow - 1988
QUALIFICATIONS: experience in synthesis of oligosaccharides, neoglycoconjugates; study of specificity for lectins and anti-carbohydrate antibodies; carbohydrate analysis
CURRENT RESEARCH INTERESTS: supramolecular chemistry; glycoarrays; carbohydrate/protein and carbohydrate/carbohydrate interaction; synthesis of oligosaccharides and neoglycoconjugates; structural analysis of glycoproteins; immune responce to carbohydrates; xenotransplantation; natural killers; medicinal chemistry: influenza therapy, transplantation, oncodiagnostics and oncotargeting, inflammation, atherosclerosis.
Position: head of the laboratory Phone: +7 495 330-71-38; Fax: +7 495 330-55-92
1. G.V.Pazynina, T.V.Tyrtysh, V.V.Nasonov, I.M.Belyanchikov, A.Paramonov, N.Malysheva, L.O.Kononov, N.V.Bovin, etc. Divergent strategy for the synthesis of α2-3-linked sialo-oligosaccharide libraries using a Neu5TFA-(α2-3)-Gal building block. Synlett, 24, pp.226-230, (2013) []
2. C.Rosenberg, N.V.Bovin, L.V. Bram, E.Flyvbjerg, M.Erlandsen, T.Vorup-Jensen, E.Petersen Age is an important determinant in humoral and T cell responses to immunization with hepatitis B surface antigen Hum Vaccin Immunother, 9(7)(Epub ahead of print), (2013) [] [PMID: 23571167]
3. F.Zhang, B.Walcott, D.Zhou, A.Gustchina, Y.Lasanajak, D.F.Smith, R.S.Ferreira, N.V.Bovin, etc. Structural Studies of the Interaction of Crataeva tapia Bark Protein with Heparin and Other Glycosaminoglycans Biochemistry, Mar 14(Epub ahead of print), (2013) [] [PMID: 23448527]
4. O.E.Galanina, A.A.Chinarev, N.V.Shilova, M.A.Sablina, N.V.Bovin Immobilization of polyacrylamide-based glycoconjugates on solid phase in immunosorbent assays. Methods Mol. Biol., 808, pp.167-182, (2012) [] [PMID: 22057525]
5. I.M.Ryzhov, E.Yu.Korchagina, I.S.Popova, N.V.Bovin Block synthesis of A tetrasaccharides (types 1, 3, and 4) related to the human ABO blood group system. Carbohydrate Research, 351, pp.17-25, (2012) [] [PMID: 22305408]
6. G.V.Pazynina, I.S.Popova, I.M.Belyanchikov, A.B.Tuzikov, N.V.Bovin Synthesis of trisaccharide 6'SiaLeC and its 6-O-Su derivative. Mendeleev Communs., 22(4), pp.194-195, (2012) []
7. N.V.Shilova, M.Navakouski, N.Khasbiullina, O.Blixt, N.V.Bovin Printed glycan array: antibodies as probed in undiluted serum and effects of dilution Glycoconjugate Journal, 29(2-3), p.87, (2012) [] [PMID: 22258790]
8. F.Jacob, D.R.Goldstein, M.E.Huflejt, N.V.Bovin, T.V.Pochechueva, M.Spengler, R.Caduff, D.Fink, etc. Serum antiglycan antibody detection of epithelial ovarian cancers by using a printed glycan array. Int. J. Cancer, 130, pp.138-146, (2012) [] [PMID: 21351089]
9. N.V.Bovin, P.Obukhova, N.V.Shilova, I.S.Popova, M.Navakouski, C.Unverzagt, M.I.Vuskovic, M.E.Huflejt Repertoire of human natural anti-glycan immunoglobulins. Do we have auto-antibodies? Biochemica Biophysica Acta, 1820, pp.1373-1382, (2012) [] [PMID: 22365885]
10. Y.Banz, O.M.Hess, E.Yu.Korchagina, E.A.Gordeeva, S.C.Robson, E.Csizmadia, D.Mettler, N.V.Bovin, etc. Evaluation of multimeric tyrosine-O-sulfate as a cytoprotectant in an in vivo model of acute myocardial infarction in pigs. Cardiology, 121, pp.59-70, (2012) [] [] [PMID: 22398380]
11. A.S.Gambaryan, T.Y.Matrosovich, J.Philipp, V.J.Munster, R.A.Fouchier, G.Cattoli, I.Capua, N.V.Bovin, etc. Receptor-binding profiles of H7 subtype influenza viruses in different host species. J. Virol., 86(8), pp.4370-4379, (2012) [] [] [PMID: 22345462]
13. I.A.Rudneva, A.Ignatieva, T.Timofeeva, A.A.Shilov, A.Kushch, O.Masalova, R.Klimova, N.V.Bovin, etc. Escape mutants of pandemic influenza A/H1N1 2009 virus: variations in antigenic specificity and receptor affinity of the hemagglutinin. Virus Res., 166, pp.61-67, (2012) [] [PMID: 22459010]
14. N.A.Ilyushina, N.V.Bovin, R.G.Webster Decreased neuraminidase activity is important for the adaptation of H5N1 influenza virus to human airway epithelium. J. Virol., 86, pp.4724-4733, (2012) [] [] [PMID: 22379077]
15. O.A.Vokhmyanina, E.M.Rapoport, S.André, V.V.Severov, I.M.Ryzhov, G.V.Pazynina, E.Yu.Korchagina, N.V.Bovin, etc. Comparative study of the glycan specificities of cell-bound human tandem-repeat-type galectin-4, -8 and -9. Glycobiology, 22(1), pp.207-217, (2012) [] [] [PMID: 22547138]
16. Z.Pail, P.Antal, S.K.Srivastava, G.Hullm, A.F.Semsei, J.Gl, M.Svbis, N.V.Bovin, etc. Non-synonymous single nucleotide polymorphisms in genes for immunoregulatory galectins: Association of galectin-8 (F19Y) occurrence with autoimmune diseases in a Caucasian population. Biochemica Biophysica Acta, 1820, pp.1512-1518, (2012) [] [] [PMID: 22683700]
17. M.F.Ducatez, N.A.Ilyushina, T.P.Fabrizio, J.E.Rehg, N.V.Bovin, R.G.Webster, R.J.Webby Both influenza hemagglutinin and polymerase acidic genes are important for delayed pandemic 2009 H1N1 virus clearance in the ferret model. Virology, 432(2), pp.389-393, (2012) [] [] [PMID: 22809692]
18. D.K.Lvov, M.Shchelkanov, N.V.Bovin, N.A.Malyshev, A.G.Chuchalin, L.V.Kolobukhina, A.G.Prilipov, V.S.Bogdanova, etc. Correlation between the receptor specificity of pandemic influenza A (H1N1)pdm09 virus strains isolated in 2009-2011 and the structure of the receptor-binding site and the probability of fatal primary viral pneumonia. Vopr. Virusol. (Rus.), 57(1), pp.14-20, (2012) [] [PMID: 22624468]
19. K.Govindasamy, S.A.Machado, C.Korneli, E.Collins, P.Miller, K.N.Bess, K.Aoki, N.V.Bovin, etc. Porcine Sperm Bind to Specific 6-Sialylated Biantennary Glycans to Form the Oviduct Reservoir. Biology of Reproduction, 87(6), p.147, (2012) [] [] [PMID: 23115267]
20. E.V.Moiseeva, N.R.Kuznetsova, E.V.Svirshchevskaya, N.V.Bovin, N.C.Sitnikov, A.C.Shavyrin, I.P.Beletskaia, S.Combes, etc. Liposome formulations of combretastatin A4 and 4-arylcoumarin analog prodrugs: antitumor effect in the mouse model of breast cancer. [Article in Russian] Biomedical Chemistry, 58, pp.326-338, (2012) [] [PMID: 22856138]
21. O.Blixt, O.I.Lavrova, D.V.Mazurov, E.Cló, S.K.Kracun, N.V.Bovin, A.V.Filatov Analysis of Tn antigenicity with a panel of new IgM and IgG1 monoclonal antibodies raised against leukemic cells. Glycobiology, 22(4), pp.529-542, (2012) [] [PMID: 22143985]
23. E.I.Vodovozova, G.V.Pazynina, N.V.Bovin Synthesis of diglyceride conjugate of selectin ligand SiaLeX as a vector for targeting of drug-loaded liposomes. Mendeleev Communs., 21(2), pp.69-71, (2011) []
28. M.E.Otto, M.A.Campanero-Rhodes, R.Karamanska, A.K.Powell, N.V.Bovin, J.E.Turnbull, T.Feizi, P.Crocker, etc. An expression system for screening of proteins for glycan and protein interactions. Analytical Biochemistry, 411(2), pp.261-270, (2011) [] [PMID: 21211507]
29. V.V.Prokhorov, D.V.Klinov, A.A.Chinarev, A.B.Tuzikov, I.V.Gorokhova, N.V.Bovin High-resolution atomic force microscopy study of hexaglycylamide epitaxial structures on graphite. Langmuir, 27, pp.5879-5880, (2011) [] [] [PMID: 21351798]
30. F.Jacob, D.R.Goldstein, M.E.Huflejt, N.V.Bovin, T.V.Pochechueva, M.Spengler, R.Caduff, D.Fink, etc. Serum antiglycan antibody detection of nonmucinous ovarian cancers by using a printed glycan array. Int. J. Cancer, 130(1), pp.138-146, (2011) [] [PMID: 21351089]
