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Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
Nicolai Bovin , Professor

CURRICULUM VITAE

EDUCATION

  • Moscow State University, Department of Chemistry, 1971-1976, M.Sc.Thesis "Synthesis and cycloaddition reactions of 3,3-disubstituted cyclopropenes", Supervisor Dr. I.G.Bolesov, Laboratoty of Organic Synthesis.
  • Ph.D.Thesis "Synthesis of blood group related oligosaccharides H, A, and Lea, and their immobilisation on polymeric matrix", 1982, Institute of Bioorganic Chemistry, Laboratory of Carbohydrates and Glycoproteins (Prof. A.Ya.Khorlin).
  • Dr.Sci. Thesis "Neoglycoconjugates: synthesis and application for hemo- and oncodiagnostics", 1993, Institute of Bioorganic Chemistry.

CARRIER/EMPLOYMENT

  • Research scientist - 1976, Shemyakin Institute, Moscow
  • Dr. (candidate, equivalent to Ph.D.) - 1982, Shemyakin Institute, Moscow
  • Dr. Sci., in chemistry, - 1993, Shemyakin Institute, Moscow
  • Head of research laboratory, Institute of Biotechnology, Moscow - 1985
  • Head of research laboratory, Shemyakin Institute, Moscow - 1988
  • Professor, 2001

JOB OBJECTIVE. Carbohydrates: chemistry, biochemistry, immunochemistry, microarrays; supramolecular chemistry; carbohydrate-protein interaction; lectins; chemo-medical approaches in: cancer, influenza, inflammation, transplantation

QUALIFICATIONS: experience in synthesis of oligosaccharides, neoglycoconjugates; study of specificity for lectins and anti-carbohydrate antibodies; carbohydrate analysis


CURRENT RESEARCH INTERESTS: supramolecular chemistry; glycoarrays; carbohydrate/protein and carbohydrate/carbohydrate interaction; synthesis of oligosaccharides and neoglycoconjugates; structural analysis of glycoproteins; immune responce to carbohydrates; xenotransplantation; natural killers; medicinal chemistry: influenza therapy, transplantation, oncodiagnostics and oncotargeting, inflammation, atherosclerosis.



Position: head of the laboratory
Phone: +7 495 330-71-38; Fax: +7 495 330-55-92
Skype: NicolaiVBovin
E.mail:  Send mail
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Publications: (total 416, shown from 1 to 30) [print version]

1. G.V.Pazynina, A.A.Chinarev, A.B.Tuzikov, V.V.Nasonov, N.Malysheva, N.V.Bovin
Synthesis of a Spacer-Armed 6′-Sialyl-N-Acetyllactosamine
In Carbohydrate Chemistry Proven Synthetic Methods, Vol. 2, , Codee, J., van der Marel, G. (eds.) CRC PressTaylor Francis, Boca Raton, FL, pp.155-160, (2014) [abstract] [full PDF]

2. Y.A.Knirel, H.-J.Gabius, O.Blixt, E.M.Rapoport, N.R.Khasbiullina, N.V.Shilova, N.V.Bovin
Human tandem-repeat-type galectins bind bacterial non-βGal polysaccharides.
Glycoconjugate Journal, 31(1), pp.7-12, (2014) [abstract] [PMID: 24065176]

3. S.V.Tsygankova, A.A.Chinarev, A.B.Tuzikov, N.Severin, A.A.Kalachev, J.P.Rabe, A.S.Gambaryan, N.V.Bovin
Biantennary oligoglycines and glyco-oligoglycines self-associating in aqueous medium
Beilstein J. Org. Chem., 10, pp.1372-1382, (2014) [abstract] [full PDF]

4. G.V.Pazynina, T.V.Tyrtysh, V.V.Nasonov, I.M.Belyanchikov, A.Paramonov, N.Malysheva, L.O.Kononov, N.V.Bovin, etc.
Divergent strategy for the synthesis of α2-3-linked sialo-oligosaccharide libraries using a Neu5TFA-(α2-3)-Gal building block.
Synlett, 24, pp.226-230, (2013) [abstract]

5. N.R.Kuznetsova, E.V.Stepanova, N.M.Peretolchina, D.A. Khochenkov, I.A. Boldyrev, N.V.Bovin, E.I.Vodovozova
Targeting liposomes loaded with melphalan prodrug to tumour vasculature via the Sialyl Lewis X selectin ligand
J Drug Target, Dec 9(Epub ahead of print), (2013) [abstract] [PMID: 24313904]

6. C.Rosenberg, N.V.Bovin, L.V. Bram, E.Flyvbjerg, M.Erlandsen, T.Vorup-Jensen, E.Petersen
Age is an important determinant in humoral and T cell responses to immunization with hepatitis B surface antigen.
Hum Vaccin Immunother, 9(7), pp.1466-1476, (2013) [abstract]

7. F.Zhang, B.Walcott, D.Zhou, A.Gustchina, Y.Lasanajak, D.F.Smith, R.S.Ferreira, N.V.Bovin, etc.
Structural Studies of the Interaction of Crataeva tapia Bark Protein with Heparin and Other Glycosaminoglycans.
Biochemistry, 52(12), pp.2148-2156, (2013) [abstract] [PMID: 23448527]

8. E.V.Moiseeva, N.R.Kuznetsova, E.V.Svirshchevskaya, N.V.Bovin, N.C.Sitnikov, A.C.Shavyrin, I.P.Beletskaia, E.I.Vodovozova, etc.
Liposome formulations of combretastatin A4 and 4-arylcoumarin analog prodrugs: antitumor effect in the mouse model of breast cancer [Article in Russian]
Biomed Khim, 58(3), pp.326-338, (2013) [abstract] [PMID: 22856138]

9. T.A.Timofeeva, I.A.Rudneva, L.V.Mochalova, N.V.Bovin, N.V.Kaverin
Effect of mutations changing the antigenic specificity on the receptor-binding activity of the influenza virus hemagglutinin of H1 and H5 subtypes. [Article in Russian]
Vopr. Virusol. (Rus.), 58(1), pp.24-27, (2013) [abstract] [PMID: 23785757]

10. N.V.Bovin
Natural antibodies to glycans.
Biochemistry (Moscow), 78(7), pp.1008-1022, (2013) [abstract] [PMID: 24010841]

11. A.A.Chinarev, S.V.Tsygankova, I.V.Kubrakova, N.V.Bovin
Insulation and concentration of adenosine triphosphate under prebiotic conditions: Hypothesis and experimental data.
In Problems of Biosphere Origin and Evolution, Vol. 1, E.M. Galimov, Ed. Nova Science Publishers, NY, US, Vol. 1, pp.167-176, (2013) [abstract]

12. O.E.Galanina, A.A.Chinarev, N.V.Shilova, M.A.Sablina, N.V.Bovin
Immobilization of polyacrylamide-based glycoconjugates on solid phase in immunosorbent assays.
Methods Mol. Biol., 808, pp.167-182, (2012) [abstract] [full PDF] [PMID: 22057525]

13. I.M.Ryzhov, E.Yu.Korchagina, I.S.Popova, N.V.Bovin
Block synthesis of A tetrasaccharides (types 1, 3, and 4) related to the human ABO blood group system.
Carbohydrate Research, 351, pp.17-25, (2012) [abstract] [PMID: 22305408]

14. G.V.Pazynina, I.S.Popova, I.M.Belyanchikov, A.B.Tuzikov, N.V.Bovin
Synthesis of trisaccharide 6'SiaLeC and its 6-O-Su derivative.
Mendeleev Communs., 22(4), pp.194-195, (2012) [abstract]

15. N.V.Shilova, M.Navakouski, N.R.Khasbiullina, O.Blixt, N.V.Bovin
Printed glycan array: antibodies as probed in undiluted serum and effects of dilution
Glycoconjugate Journal, 29(2-3), p.87, (2012) [abstract] [PMID: 22258790]

16. F.Jacob, D.R.Goldstein, M.E.Huflejt, N.V.Bovin, T.V.Pochechueva, M.Spengler, R.Caduff, D.Fink, etc.
Serum antiglycan antibody detection of epithelial ovarian cancers by using a printed glycan array.
Int. J. Cancer, 130, pp.138-146, (2012) [abstract] [PMID: 21351089]

17. N.V.Bovin, P.Obukhova, N.V.Shilova, I.S.Popova, M.Navakouski, C.Unverzagt, M.I.Vuskovic, M.E.Huflejt
Repertoire of human natural anti-glycan immunoglobulins. Do we have auto-antibodies?
Biochemica Biophysica Acta, 1820, pp.1373-1382, (2012) [abstract] [PMID: 22365885]

18. Y.Banz, O.M.Hess, E.Yu.Korchagina, E.A.Gordeeva, S.C.Robson, E.Csizmadia, D.Mettler, N.V.Bovin, etc.
Evaluation of multimeric tyrosine-O-sulfate as a cytoprotectant in an in vivo model of acute myocardial infarction in pigs.
Cardiology, 121, pp.59-70, (2012) [abstract] [full PDF] [PMID: 22398380]

19. A.S.Gambaryan, T.Y.Matrosovich, J.Philipp, V.J.Munster, R.A.Fouchier, G.Cattoli, I.Capua, N.V.Bovin, etc.
Receptor-binding profiles of H7 subtype influenza viruses in different host species.
J. Virol., 86(8), pp.4370-4379, (2012) [abstract] [full PDF] [PMID: 22345462]

20. E.Yu.Korchagina, A.B.Tuzikov, A.A.Formanovsky, I.S.Popova, S.Henry, N.V.Bovin
Toward creating cell membrane glyco-landscapes with glycan lipid constructs.
Carbohydrate Research, 356, pp.238-246, (2012) [abstract] [full PDF] [PMID: 22551471]

21. I.A.Rudneva, A.Ignatieva, T.A.Timofeeva, A.A.Shilov, A.Kushch, O.Masalova, R.Klimova, N.V.Bovin, etc.
Escape mutants of pandemic influenza A/H1N1 2009 virus: variations in antigenic specificity and receptor affinity of the hemagglutinin.
Virus Res., 166, pp.61-67, (2012) [abstract] [PMID: 22459010]

22. N.A.Ilyushina, N.V.Bovin, R.G.Webster
Decreased neuraminidase activity is important for the adaptation of H5N1 influenza virus to human airway epithelium.
J. Virol., 86, pp.4724-4733, (2012) [abstract] [full PDF] [PMID: 22379077]

23. O.A.Vokhmyanina, E.M.Rapoport, S.André, V.V.Severov, I.M.Ryzhov, G.V.Pazynina, E.Yu.Korchagina, N.V.Bovin, etc.
Comparative study of the glycan specificities of cell-bound human tandem-repeat-type galectin-4, -8 and -9.
Glycobiology, 22(1), pp.207-217, (2012) [abstract] [full PDF] [PMID: 22547138]

24. Z.Pail, P.Antal, S.K.Srivastava, G.Hullm, A.F.Semsei, J.Gl, M.Svbis, N.V.Bovin, etc.
Non-synonymous single nucleotide polymorphisms in genes for immunoregulatory galectins: Association of galectin-8 (F19Y) occurrence with autoimmune diseases in a Caucasian population.
Biochemica Biophysica Acta, 1820, pp.1512-1518, (2012) [abstract] [full PDF] [PMID: 22683700]

25. M.F.Ducatez, N.A.Ilyushina, T.P.Fabrizio, J.E.Rehg, N.V.Bovin, R.G.Webster, R.J.Webby
Both influenza hemagglutinin and polymerase acidic genes are important for delayed pandemic 2009 H1N1 virus clearance in the ferret model.
Virology, 432(2), pp.389-393, (2012) [abstract] [full PDF] [PMID: 22809692]

26. D.K.Lvov, M.Shchelkanov, N.V.Bovin, N.A.Malyshev, A.G.Chuchalin, L.V.Kolobukhina, A.G.Prilipov, V.S.Bogdanova, etc.
Correlation between the receptor specificity of pandemic influenza A (H1N1)pdm09 virus strains isolated in 2009-2011 and the structure of the receptor-binding site and the probability of fatal primary viral pneumonia.
Vopr. Virusol. (Rus.), 57(1), pp.14-20, (2012) [abstract] [PMID: 22624468]

27. K.Govindasamy, S.A.Machado, C.Korneli, E.Collins, P.Miller, K.N.Bess, K.Aoki, N.V.Bovin, etc.
Porcine Sperm Bind to Specific 6-Sialylated Biantennary Glycans to Form the Oviduct Reservoir.
Biology of Reproduction, 87(6), p.147, (2012) [abstract] [full PDF] [PMID: 23115267]

28. E.V.Moiseeva, N.R.Kuznetsova, E.V.Svirshchevskaya, N.V.Bovin, N.C.Sitnikov, A.C.Shavyrin, I.P.Beletskaia, S.Combes, etc.
Liposome formulations of combretastatin A4 and 4-arylcoumarin analog prodrugs: antitumor effect in the mouse model of breast cancer. [Article in Russian]
Biomedical Chemistry, 58, pp.326-338, (2012) [abstract] [PMID: 22856138]

29. O.Blixt, O.I.Lavrova, D.V.Mazurov, E.Cló, S.K.Kracun, N.V.Bovin, A.V.Filatov
Analysis of Tn antigenicity with a panel of new IgM and IgG1 monoclonal antibodies raised against leukemic cells.
Glycobiology, 22(4), pp.529-542, (2012) [abstract] [PMID: 22143985]

30. S.V.Tsygankova, A.A.Chinarev, A.B.Tuzikov, I.S.Zaitsev, N.Severin, A.A.Kalachev, J.P.Rabe, N.V.Bovin
Assembly of oligoglicine layers on mica surface.
Biomater. Nanobiotechnol., 2, pp.90-96, (2011) [abstract] [full PDF]

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