Divergent strategy for the synthesis of α2-3-linked sialo-oligosaccharide libraries using a Neu5TFA-(α2-3)-Gal building block.
Synlett, 24, pp. 226 - 230, (2013)
1 M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, ul. Miklukho-Maklaya, 16/10, Moscow 117997, GSP-7, Russian Federation
2 N. D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, Leninsky prosp., 47, Moscow 119991, Russian Federation
A novel Neu5TFA-(α2-3)-Gal building block with removable protecting group at N5′ was introduced and used in the divergent synthesis of a library of N-acetyl and N-glycolyl derivatives of oligosaccharides related to sialyl-(α2-3)-N-acetyl-lactosamine and sialyl-(α2-3)-N-acetyl-isolactosamine, with or without sulfate at O6 of glucosamine residue.