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Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
Abstract
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E.Yu.Korchagina, A.B.Tuzikov, A.A.Formanovsky, I.S.Popova, S.Henry, N.V.Bovin
Toward creating cell membrane glyco-landscapes with glycan lipid constructs.
Carbohydrate Research, 356, pp. 238 - 246, (2012)

Shemyakin Institute of Bioorganic Chemistry RAS, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.

Synthetic glycolipid-like constructs dispersible in biological media and capable of incorporating into cell membranes have the ability to create novel artificial glyco-landscapes on living cells. Using a variety of different glycans ranging from disaccharides to polysaccharides, together with different lengths and high hydrophilicity spacers, we created a series of synthetic glycolipid-like constructs. Contacting these constructs with live cells gave modified cells with controlled glycan density and/or altered biological function. The ability to also use these constructs as solutions to inhibit antibodies, toxins, and virions extends the potential diagnostic and therapeutic uses for these synthetic glycolipid-like constructs.

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