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Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
Abstract
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S.D.Shiyan, V.V.Nasonov, N.V.Bovin, V.A.Aleshkin, L.I.Novikova, A.G.Lutov
Structure of the carbohydrate chains of molecular forms of the α1-acid glycoprotein from the ascitic fluid of stomach cancer patients. [Article in Russian]
Russ. J. Bioorgan. Chem., 20 (10), pp. 1125 - 1131, (1994)

The immunochemically pure α1-acid glycoprotein (aAGP) from ascitic fluid of patients with stomach cancer was separated by chromatography on Con A-Sepharose into Con A-nonbound (aAGP-1, 43, 5 kDa, 70%) and Con A-bound (aAGP-2, 41.5 kDa, 24% and aAGP-3, 40.0 kDa, 5%) forms, differing in the monosaccharide composition. Comparative study of structures of their N-carbohydrate chains with the aid of the HPLC of fluorescence-labelled oligosaccharides showed that the molecular forms differ by the ratio of the di-, tri-, and tetraantennary carbohydrate N-chains of a complex type. The molecular forms of aAGP differ from nAGP by amounts of Lex-fragments and agalacto-oligosaccharides.

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